Eimeria vermiformis Infection Model of Murine Small Intestine

T-Cell Receptor gd Lymphocytes and Eimeria vermiformis Infection

Intestinal intraepithelial lymphocytes sustain the epithelial barrier function against Eimeria vermiformis infection.

Eimeria spp. are intracellular protozoa that infect intestinal epithelia of most vertebrates, causing coccidiosis. Intestinal intraepithelial lymphocytes (IEL) that reside at the basolateral site of epithelial cells (EC) have immunoregulatory and immunoprotective roles against Eimeria spp. infection. However, it remains unknown how IEL are involved in the regulation of epithelial barrier during...

Immune regulation of protease-activated receptor-1 expression in murine small intestine during Nippostrongylus brasiliensis infection.

Infection with gastrointestinal nematodes exerts profound effects on both immune and physiological responses of the host. Helminth infection induces a hypercontractility of intestinal smooth muscle that is dependent on the Th2 cytokines, IL-4 and IL-13, and may contribute to worm expulsion. Protease-activated receptors (PARs) are expressed throughout the gut, and activation of PAR-1 was observe...

Genome-wide analysis of PPAR activation in murine small intestine

Bünger M, van den Bosch HM, van der Meijde J, Kersten S, Hooiveld GJ, Müller M. Genome-wide analysis of PPAR activation in murine small intestine. Physiol Genomics 30: 192–204, 2007. First published April 10, 2007; doi:10.1152/physiolgenomics.00198.2006.— The peroxisome proliferator-activated receptor alpha (PPAR ) is a fatty acid-activated transcription factor that governs a variety of biologi...

Cryptdins: antimicrobial defensins of the murine small intestine.

Paneth cells are specialized small intestine epithelial cells that contain lysozyme, possess phagocytic properties, and secrete cytoplasmic granules into the intestinal crypt lumen after the entry of bacteria. Recent studies by Ouellette and associates (A. J. Ouellette, R. M. Greco, M. James, D. Frederick, J. Naftilan, and J. T. Fallon, J. Cell Biol. 108:1687-1695, 1989) indicated that murine P...